A Guide to your ACLASTA® Infusion

What is ALCASTA® (Zoledronic acid)?

Aclasta® is a medicine for the treatment of osteoporosis and people who are at increased risk of fracture (broken bones). The active substance is called zoledronic acid.

How does ACLASTA® work?

Aclasta® works by attaching to bone, preventing it from breaking down too much and protecting it from further breakdown. Your doctor can check that Aclasta® is working by carrying out tests such as bone mineral density assessment and bone turnover markers (blood test). The usual dose of Aclasta® is 5 mg given as an intravenous infusion every year for 5 years. It is administered by our nurse. Although the infusion takes about 15 minutes plan to spend up to 1 hour with us to have the infusion and some post infusion monitoring.

What should I do before I get my ACLASTA®?

It is important to drink plenty of fluids, preferrably water (at least one or two glasses) before your infusion of Aclasta®. Taking paracetamol 500mg x 2 tablets before you come for the infusion and twice daily after the infusion for 24-48 hours after will help reduce the risk of side effects.

How will I feel after my infusion of ACLASTA®?

Some people may have side effects when they receive Aclasta®.

People taking Aclasta® can experience:

  • Flu-like symptoms, such as fever and chills but these lessen after each infusion.

  • Pain in the muscles, bones or joints

  • Headache

Most of these side effects occur within the first 48 hours following the infusion of Aclasta®. They are usually mild or moderate and usually go away within three days of the infusion

If the symptoms do not go away or get worse, or you have questions you should speak to your doctor. Our nurse is happy to answer any questions at the time of your infusion.

The Importance of a healthy lifestyle whilst taking ACLASTA®

A healthy lifestyle plays an important part in keepog your bones strong. There are things that you can do to help:

  • A healthy balanced diet is very important with added calcium and vitamin D supplements.

  • Physical activity, especially weight bearing exercise such as walking, are important in keeping the bone and muscles strong and healthy.

  • Stop or reduce smoking and making sure your alcohol intake is healthy.

A healthcare worker in blue gloves drawing blood from a patient's arm in a clinical setting.